Research-focused article previewing work on boosting a neuronal trafficking protein to slow tau-driven neurodegeneration, with experimental mouse-model evidence.
Key Takeaways
- Up-regulating the endosomal trafficking receptor SORLA reduced tau phosphorylation and seeding in a PS19 mouse model
- Increased SORLA expression lessened synapse loss, ventricular enlargement, and LTP impairment in aged tauopathy mice
- SORLA up-regulation also decreased glial hyperactivation, suggesting reduced neuroinflammation linked to tau toxicity