Human aging and microglia origins — a research article that maps how immune-lineage cells populate the brain over a lifetime, promising new insights into brain immune dynamics.
Key Takeaways
- Lineage tracing of somatic mutations found marrow-derived myeloid cells infiltrate aged human brains
- Single-cell and mitochondrial variant analyses show these infiltrating cells resemble resident microglia
- Most types of clonal hematopoiesis were associated with reduced Alzheimer’s disease risk in cohort analyses