Read about a citrus-derived phytochemical's effects on diet-driven gut barrier disruption and liver dysfunction through mitophagy and inflammatory pathways.
Key Takeaways
- Sinensetin reversed established high-fat diet-induced liver injury and restored intestinal barrier function
- It activated PINK1/Parkin-mediated mitophagy while suppressing TLR4/MAPK inflammatory signaling
- Treatment reduced pro-inflammatory cytokines and markers of hepatic steatosis and fibrosis