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Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999–2018 with external support from an imaging-confirmed hemorrhagic stroke dataset

Source: Frontiers - Health • Published: 26 Jun 2026, 00:00

Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999–2018 with external support from an imaging-confirmed hemorrhagic stroke dataset

Evaluation of a combined uric acid to HDL cholesterol index across national survey data and an external cohort assessing links with stroke prevalence.

Key Takeaways
  • Top UHR quartile had approximately 37% higher stroke prevalence than lowest quartile
  • Restricted cubic spline analyses showed an approximately linear UHR–stroke association
  • Independent Chinese hemorrhagic stroke cohort found directionally consistent associations with UHR
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