Reports an exploratory serum lipidomics study linking early post-stroke lipid changes to later cognitive decline and evaluates predictive models integrating lipids and clinical data.
Key Takeaways
- In 123 acute ischemic stroke patients, 62 developed post-stroke cognitive impairment at three months
- Lipidomics found 1,584 annotated lipids with 65 nominally associated with PSCI after clinical adjustment
- Combined clinical plus lipidomic model achieved AUC 0.763 in internal validation