A new paper proposes a unifying theory that challenges plaque-first thinking about what initiates Alzheimer’s disease.
Key Takeaways
- Disruption of neuronal microtubules may initiate the cascade linking amyloid-beta and tau pathologies
- Microtubule instability can explain how amyloid-beta and tau reciprocally accelerate neurodegeneration
- Therapies stabilizing microtubules or preventing their disruption could offer earlier disease intervention