Report on a molecular switch linked to age-related protein aggregation in the nervous system and its effects on neuronal health and lifespan.
Key Takeaways
- EPS8 accumulation in aging worms drives RAC signaling hyperactivation and promotes toxic protein aggregation
- Reducing EPS8 activity prevented harmful protein aggregates and preserved neuronal function in the model
- Study links EPS8-related signaling to shortened lifespan in the worm model