Report on a newly mapped brain-to-gut-to-bone marrow pathway in mice linking chronic stress to immune stem cell aging and microbiome loss.
Key Takeaways
- Reduced activity in two stress-sensitive brain regions caused blood stem cell dysfunction in mice
- Neural signals to the gut depleted Lactobacillus reuteri and lowered spermidine production
- Transferring microbiota from stressed mice induced premature blood stem cell aging in recipients