Describes a programmable antisense oligonucleotide strategy that blocks local RNA structures to prevent diverse RNA modifications at specific sites.
Key Takeaways
- Moreover, this strategy achieves comparable or superior performance when dCas13-eraser-based systems are applicable
- Data availability All sequencing data are available in the NCBI GEO database under accession GEO PRJNA1367978
- Programmable m 6 A modification of cellular RNAs with a Cas13-directed methyltransferase