This research-focused article previews a mouse-based study about how tissue macrophages' failure to clear aged neutrophils may drive organ aging and explores restoring that clearance as a therapeutic angle.
Key Takeaways
- Deleting EP2 in tissue-resident macrophages restored mitochondrial fitness and immune homeostasis in aged mice
- Senescent CXCR4+ neutrophils accumulated in aging organs and displayed SASP
- EP2 inhibition improved macrophage efferocytosis of senescent neutrophils and reversed cognitive