Report on a synthetic peptide candidate that lowered physiological and behavioral stress markers in a rodent chronic unpredictable stress model.
Key Takeaways
- PT00114 reduced stress-induced plasma corticosterone by 56.4% versus controls
- Two 250 nmol/kg subcutaneous doses caused behavioral and physiological stress reductions
- PT00114 completed single and multiple dose Phase 1 studies with favorable topline safety