Examine research probing how cleaved transfer RNA fragments influence cellular stress responses and their potential connections to aging across species.
Key Takeaways
- DIS-3/DIS3 was identified as an evolutionarily conserved ribonuclease generating tRNA halves
- In worms 5'-tRH-Gln is required for lifespan extension from dietary restriction
- Mammalian DIS3 promotes tRH production and delays cellular senescence by reducing translation