Describes ContactSeek, an AlphaFold3 contact-probability framework that pinpoints specificity-determining residues to improve base editor precision.
Key Takeaways
- Achieving high specificity in biochemical transformations is crucial for research and therapeutics
- Current strategies are constrained by activity-specificity trade-offs, high labour intensity and low success rates 3 , 4
- ContactSeek can also be applied modularly and identified key residues in the TadA8e deaminase