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Pneumococcal conjugate vaccines and antimicrobial resistance: serotype replacement, clonal dynamics, and future vaccine perspectives

Source: Frontiers - Health • Published: 24 Jul 2026, 00:00

Pneumococcal conjugate vaccines and antimicrobial resistance: serotype replacement, clonal dynamics, and future vaccine perspectives

A mini review analyzes how pneumococcal conjugate vaccines reshape antimicrobial resistance through serotype replacement, clonal shifts, and vaccine design implications.

Key Takeaways
  • We examine PCV-associated AMR dynamics through linked epidemiological
  • We then explain why these effects are incomplete
  • We argue that next-generation pneumococcal vaccines should be evaluated not only by immunogenicity and serotype coverage
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