Summarized by Masters of Longevity from medRxiv.
Report on a hospital study showing plasma neurofilament light chain concentrations distinguish delirium from dementia and psychiatric presentations using a specific diagnostic threshold.
Key Takeaways
- In Phase 1 (n=176) delirium patients had higher plasma NfL than dementia and PPD groups after covariate adjustment.
- An NfL threshold of about 24.1 pg/mL discriminated delirium with AUC 0.89, 96% sensitivity and 70% specificity.
- Phase 2 validation (n=154) confirmed the >24 pg/mL threshold with AUC 0.95, 96% sensitivity and 77% specificity.
