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Optimization of Stropharia rugosoannulata extracts using artificial intelligence and response surface methodology and comparative evaluation of their biological activities

Source: Nature - Biotechnology • Published: 10 Aug 2026, 00:00

Optimization of Stropharia rugosoannulata extracts using artificial intelligence and response surface methodology and comparative evaluation of their biological activities

Optimizing extraction from an edible mushroom using AI and statistical modeling, this article previews a comparative study of resulting bioactive extracts and their measured activities.

Key Takeaways
  • Response Surface Methodology produced extracts with higher antioxidant capacity than ANN-GA optimized extracts
  • RSM extracts showed stronger acetylcholinesterase and butyrylcholinesterase inhibition than ANN-GA extracts
  • RSM extracts had greater antiproliferative effects against A549, MCF-7, and DU-145 cancer cell lines
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