Reports a biomaterials strategy combining cell-penetrating peptide–modified calcium phosphate nanoparticles and a small molecule to boost plasmid gene delivery and promote bone formation in a rat skull defect model.
Key Takeaways
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- Amiloride improves the gene-transfection efficiency of octa-arginine (R8)-modified calcium phosphate (CaP)
- Amiloride reduced intracellular pH and increased calcium concentration