Reports on peptide-coated dermal substitutes evaluated for anti-biofilm activity and inflammatory modulation across in vitro and ex vivo wound models.
Key Takeaways
- Dual coating of Nisin and LL-37 onto the BTM dermal matrix eradicated mature polymicrobial biofilms
- BTM-AMPs reduced metabolically active bacteria by more than fifty percent within six hours ex vivo
- BTM-AMPs also dampened inflammation by lowering TNF-α levels and enhancing macrophage phagocytosis in vitro