Look at a human split-face study showing a non-ablative laser shifted skin DNA methylation patterns and paralleled visible improvement.
Key Takeaways
- Researchers profiled over 3.8 million CpG sites and found 83.9% reversal-consistent shifts
- Laser treatment modulated keratinocyte loci such as FGFR3, HOXB4, UBE2I, PPP1R18, and PPP1R26
- Brown-spot counts on the treated side fell by a median 38% at one month