Report on a GRK2-linked pathological pathway and a targeted small molecule aimed at protecting neuronal energy systems in Alzheimer's models.
Key Takeaways
- Inactivated GRK2 aggregates were observed blocking mitochondrial pores in Alzheimer's brain tissue
- Compound 10 prevented GRK2 aggregation and preserved mitochondrial energy output in experiments
- In aged Alzheimer's mice, compound 10 reduced amyloid-beta and extended survival