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Nebulized Epinephrine for Croup in Children: An Updated Systematic Review

Source: Frontiers - Health • Published: 07 Aug 2026, 00:00

Nebulized Epinephrine for Croup in Children: An Updated Systematic Review

A systematic review updates randomized trial evidence on nebulized epinephrine for pediatric croup, focusing on short‑term symptom relief and hospitalization outcomes.

Key Takeaways
  • Twelve randomized trials with 672 children were pooled in the meta-analysis
  • Nebulized epinephrine produced a significant improvement in croup score at 30 minutes post‑treatment
  • No sustained benefit was observed at 2 hours and hospital stay reduction was not statistically significant
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