Longevity News

NAT10: A potential factor to reverse tumor chemotherapy resistance and radioresistance (Review)

Source: Frontiers - Health • Published: 11 Jun 2026, 00:00

NAT10: A potential factor to reverse tumor chemotherapy resistance and radioresistance (Review)

Interested in molecular insights for tackling cancer therapy challenges? This review synthesizes recent research and translational directions.

Key Takeaways
  • Acetyltransferase is the sole known writer of RNA ac4C modification
  • It promotes therapy resistance via enhanced DNA repair, metabolic rewiring, and immune suppression
  • Specific inhibitors Remodelin and repurposed fludarabine show preclinical translational potential
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