Reports how mitochondrial metabolism and citrate export enable epigenetic activation of inflammatory SASP genes in senescent cells and in vivo aging models.
Key Takeaways
- Mitochondrial pyruvate–citrate–acetyl-CoA axis is upregulated
- Enhancing acetyl-CoA levels promotes SASP gene expression
- Signals were normalized to total histone H3 across ±5 kb from transcription start sites (TSS)