Examination of how mismatches between nuclear and mitochondrial genomes affect ageing in natural Drosophila populations and interventions that modulate that effect.
Key Takeaways
- Mitonuclear mismatch in wild Drosophila populations shortened median lifespan by about 10%
- Mismatch increased age-related mitochondrial decline and elevated reactive oxygen species production
- Early-life dietary mitochondrial stress counteracted mismatch effects and promoted mitochondrial homeostasis