Mechanistic preclinical study examining microRNA regulation of apoptosis and proliferation in renal ischemia-reperfusion injury and therapeutic implications.
Key Takeaways
- Hypoxia/reoxygenation reduced miR-144-3p levels in renal cells and mouse kidneys
- MiR-144-3p overexpression increased cell viability under hypoxia/reoxygenation in vitro
- MiR-144-3p directly targets EZH2 and EZH2 knockdown lowered apoptotic markers