Describes a human iPSC-derived tri-culture spheroid platform that integrates microglia to measure neural network activity and immune responses for disease modeling and screening.
Key Takeaways
- NeuroMIMICS, an iPSC-derived neural spheroid system containing neurons, astrocytes, and microglia
- Microglia in the spheroids showed phagocytosis, directed motility, and inflammatory cytokine responses to insults
- Introducing healthy microglia corrected alpha-synuclein A53T-induced neural network dysfunction in the model