DNA nanotechnology research article introducing a membrane‑tethered DNA construct as a customizable platform for precise, cell‑focused interventions.
Key Takeaways
- Membrane-anchored DNA nanodevice uses three allosteric aptamer arms to detect multiple surface markers simultaneously
- Concurrent binding of all three aptamers triggers an AND-logic release of doxorubicin-loaded tetrahedral DNA framework
- In tumor-bearing mice, membrane-anchored DND@Dox accumulated in tumors and reduced systemic toxicity