Assessment of targeted nanodelivery strategies to reprogram disease-associated macrophages and for evaluating translational challenges and opportunities.
Key Takeaways
- Scavenger receptors enable selective targeting of diseased macrophage populations for nanodelivery
- Cathepsin B-dependent cleavage can trigger intracellular nanocarrier disassembly and payload release
- Translational hurdles include off-target sequestration, target heterogeneity, and limited functional bioavailability