Longevity News

Macrophage polarization regulated by the βTrCP-NF-κB inflammatory signaling pathway is required for valproic acid’s dual role in breast tumor radiosensitivity and normal tissue radioprotection

Source: Frontiers - Health • Published: 10 Aug 2026, 00:00

Macrophage polarization regulated by the βTrCP-NF-κB inflammatory signaling pathway is required for valproic acid’s dual role in breast tumor radiosensitivity and normal tissue radioprotection

Covers how valproic acid modulates macrophage polarization via the βTrCP–NF-κB pathway to increase breast tumor radiosensitivity while protecting normal tissues.

Key Takeaways
  • Is a widely used treatment modality for breast cancer
  • Identifying strategies that enhance RT efficacy while minimizing adverse effects is of significant clinical importance
  • Has shown promise in augmenting the efficacy of RT
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