M2 macrophage‑derived exosomes are examined as a promising therapeutic avenue for secondary lymphedema. The study probes cellular and mitochondrial effects.
Key Takeaways
- Secondary lymphedema tissues showed increased M1 and decreased M2 macrophage infiltration
- M2-derived exosomes prevented proliferation, migration, and tube formation of lymphatic endothelial cells
- Exosome treatment activated Keap1-Nrf2 signaling and improved mitochondrial homeostasis in vitro