A review synthesizing mechanistic and spatial metabolomics evidence that specific lysophospholipids link lipid dysfunction and inflammation in atherosclerosis.
Key Takeaways
- These LPLs activate specific G protein-coupled receptors (GPCRs)
- Accumulating evidence indicates that LPLs are not passive byproducts of atherosclerotic disease
- Using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)