Low-dose dietary rapamycin research into immune aging in mice presented as a clear, engaging overview of experimental approach and implications for neuroinflammation.
Key Takeaways
- Prolonged low-dose dietary mTOR inhibition did not significantly change major immune cell populations
- Treatment selectively reduced age-related accumulation of IL-17-producing γδ T cells in the peritoneum
- Following endotoxin challenge circulating IL-17 fell and microglial inflammatory phenotype was attenuated