Describes engineering a light-activated tetanus protease that enables spatially precise, reversible proteolysis to silence synapses and control cellular outputs.
Key Takeaways
- LATeNT’s activity is undetectable in the dark
- Here we show that LATeNT works across multiple brain regions and at long-range axonal projections
- LATeNT regulated endogenous insulin secretion from pancreatic beta cells and converted drug exposure