Survey of evidence connecting gut microbiome composition to muscle and brain aging, and potential microbiome-targeting interventions for cognitive frailty.
Key Takeaways
- Animal studies show restoring youthful gut microbiota can improve health and extend lifespan
- Reduced short-chain fatty acid production and endotoxemia link dysbiosis to tissue dysfunction
- Probiotics, prebiotics, postbiotics, polyphenols, and exercise are discussed as translational interventions