Examination of how age-related shifts in bile acid composition and intestinal taurine-conjugates link to tissue aging and immune senescent cell evasion.
Key Takeaways
- Aging is a complex biological process characterized by the progressive decline in tissue and organ function
- Among the systemic factors that change with age are endogenous metabolites, including bile acids (BAs) ( 8 )
- This signaling is predominantly mediated by the nuclear Farnesoid X Receptor (FXR) ( 10 )