Protein-corona proteoform characterization invites readers into a technical study presenting analytical methods and implications for nanoparticle biomarker research.
Key Takeaways
- Top-down proteomics identified over 5,000 proteoforms originating from 400 genes
- Combining top-down and bottom-up proteomics improved characterization for about 35% of proteoforms
- Integrated dataset produced the largest human plasma proteoform collection for protein corona studies