Examination of a preclinical study on mitochondrial-targeted interventions aiming to restore intervertebral disc structure in aging models.
Key Takeaways
- SIRT3 levels inversely correlated with disc degeneration severity in human samples
- Sirt3 knockout mice developed worse disc degeneration and higher inflammation and senescence markers
- Pharmacologic Sirt3 activation improved mitochondrial function and reduced degeneration in aged mouse models