Summarized by Masters of Longevity from Nature - Biotechnology.
Demonstration of ligand-directed lipid nanoparticles that program natural killer cells in vivo to express CARs and enhance antitumor and autoimmune therapies.
Key Takeaways
- Engineered NK-targeted LNPs achieved roughly 80% NK cell transfection rates in mice with minimal off-target delivery.
- Systemic delivery of CAR mRNA via these LNPs generated CAR NK cells that fully depleted circulating B cells in healthy mice.
- CAR NK cells produced in vivo eliminated autoreactive T cells in an autoimmune hepatitis model and regressed humanized hematologic tumors.
