Assess comparative immunogenicity, efficacy, and safety across one, two, and three dose HPV vaccine schedules using a Bayesian network meta-analysis.
Key Takeaways
- Three-dose schedules ranked highest for protective efficacy against persistent HPV infection
- Single-dose schedules showed clinically significant protection versus placebo in several comparisons
- Two-dose regimens produced comparable efficacy to three-dose schedules in adolescents aged 9–14 years