Systems-level reconstruction and modelling of tumor-driven muscle wasting that maps signaling hubs linking inflammation to proteolytic responses in sarcopenia.
Key Takeaways
- Flux analysis identified cytoplasmic IL-6 export as a dominant control point
- SMAD2/3-4 mediated induction of MuRF1 and Atrogin-1 emerged as major regulators
- Immunofluorescence confirmed increased expression and relocalization of MuRF1 and Atrogin-1