Metabolic-surgery preclinical research examining molecular signaling and organ recovery after gastric bypass. Ideal for readers curious about surgical metabolism and translational insights.
Key Takeaways
- Roux-en-Y surgery reduced body weight, fasting glucose, and HOMA-IR in wild-type mice
- Post-surgery IGFBP-1 rose and IRS-1, PI3K, and AKT increased in wild-type mice
- IGFBP-1 knockout mice lacked signaling changes and showed incomplete multi-organ recovery