Health Blueprint

Back to Longevity News

News summary

Human replisomes direct a dedicated leading-strand primase for fork restart

Source: Nature - Main • Published: 11 Nov 2026, 00:00

Summarized by Masters of Longevity from Nature - Main.

PRIMPOL binds CMG and mediates leading-strand repriming after fork stalling.

Human replisomes direct a dedicated leading-strand primase for fork restart
Key Takeaways
  • PRIMPOL is directed by CMG to restart stalled leading strands.
  • Most PRIMPOL primers were placed within fifty nucleotides.
  • CMG–PRIMPOL disruption was found to abolish fork restart.
Read the full article at Nature - Main ↗

Continue exploring

Recommended MoL Picks

MoL PickNucleotides and Longevity: Is the Evidence Ready?They help build DNA and keep cells working. Early human studies make nucleotide supplements interesting—but leave important questions about healthy ageing unanswered. Yet.MoL PickBiotin for Hair Growth: The Weak Evidence—and the Blood-Test Risk Most People MissBiotin deficiency can affect hair. That does not mean more biotin makes healthy hair grow—and high doses can distort important laboratory results.MoL PickFrom Metrics to Better LivingEverstride’s May 2026 Consumer Health Market Briefing shows a wellness market moving from products to systems, from tracking to guidance, and from optimization to meaning. The next winners in longevity may not be the companies that measure the most. They may be the ones that help consumers translate health data into a life they actually want to live.