Report on cell-type resolved changes in gene regulation and 3D genome structure in the hippocampus beginning in midlife, with an immune and vascular remodeling angle.
Key Takeaways
- Key discovery shows a dramatic shift in the brain’s immune landscape between ages 50 and 75
- Combined with a marked decline in cell populations responsible for maintaining the blood-brain barrier
- Midlife human brain aging is driven by a breakdown in 3D genome architecture