Examination of how a DNA methylation pace-of-aging measure links to mortality and how systemic inflammation partly mediates that association.
Key Takeaways
- Higher DunedinPoAm quartiles were associated with graded mortality risk, with Q4 versus Q1 showing HR = 2.50
- Systemic inflammation biomarkers mediated between 2.33% and 23.5% of the mortality risk tied to DunedinPoAm
- Interactions with diabetes indicated metabolic dysregulation increases vulnerability to accelerated biological aging