Examine how a specific collagen post-translational modification changes extracellular matrix mechanics and cellular mechanotransduction after myocardial injury.
Key Takeaways
- Histaminylation of cardiac type I collagen was identified after acute myocardial infarction
- Histaminylation limited TGM2-dependent isopeptide crosslinks and lowered scar stiffness
- Local histamine-releasing hydrogel reinstated collagen histaminylation and improved cardiac function