Report on a proposed gut-lung axis where COPD-associated microbiome shifts raise serum queuine and may promote abnormal lung epithelial proliferation.
Key Takeaways
- Stable COPD patients were stratified into a high relative abundance of Proteobacteria group (CH)
- Airway microbiota profiles were analyzed in parallel to assess gut-lung axis coupling
- Serum queuine concentrations were quantified using LC-MS/MS in healthy controls