A research article examining how a processed herbal formula may affect coronary microvascular dysfunction after myocardial ischemia-reperfusion, blending chemical profiling, network pharmacology, and experimental validation to probe anti-inflammatory and endothelial-protective mechanisms.
Key Takeaways
- UHPLC-Q-Exactive HRMS identified transformed chemical constituents in the processed herbal compound GXJC
- GXJC reduced myocardial injury and improved coronary microvascular function in a murine ischemia-reperfusion model
- GXJC suppressed inflammatory responses and restored endothelial homeostasis in TNF-α stimulated human endothelial cells