Examination of a newly described pathological protein aggregation associated with mitochondrial dysfunction in Alzheimer's and potential therapeutic targeting in preclinical models.
Key Takeaways
- One might imagine other mechanisms are more involved in triggering GRK2 aggregation
- G-protein-coupled receptor kinase 2 (GRK2) exerts essential functions in cell growth and survival
- Harmful phospho-S670-GRK2 aggregation is induced by two hallmark proteins of AD