Summarized by Masters of Longevity from Longevity Technology.
Interim results from an aged-beagle study report early molecular and muscle signals after delivery of a centenarian-derived SIRT6 gene therapy, with confirmatory endpoints still pending.
Key Takeaways
- At Day 182, mean DNA methylation age fell 1.08 years in the low-dose pDNA group and 0.48 years in the high-dose group.
- Preliminary muscle histology showed preserved type II fibers and increased Pax7-positive satellite cell density in treated animals.
- Safety signals differed by vector: pDNA arms were generally tolerated, while one AAV8-treated dog developed a sustained liver-specific biochemical abnormality.
