Describes a strategy using GSDMD pore formation to deliver covalent caspase inhibitors selectively into pyroptotic cells, reducing inflammatory cytokine release.
Key Takeaways
- Covalent caspase inhibitors were designed to be excluded from healthy cells but enter through GSDMD pores
- These inhibitors blocked pyroptosis and reduced IL-1β and IL-18 secretion without preventing apoptosis
- Inhibiting caspase-1 and caspase-11 lowered IL-1β and IL-18 in a mouse endotoxic shock model